五星体育直播

五星体育直播 and Molecular Assemblies Announce Execution of Commercial License and Enzyme Supply Agreement for Optimized TdT Enzyme for Enzymatic DNA Synthesis

REDWOOD CITY, Calif. and SAN DIEGO, Aug. 02, 2022 (GLOBE NEWSWIRE) -- 聽(NASDAQ: CDXS), a leading enzyme engineering company enabling the promise of synthetic biology, and聽, a pioneer in the field of enzymatic DNA synthesis, today announced the execution of a Commercial License and Enzyme Supply Agreement, enabling Molecular Assemblies to utilize an evolved terminal deoxynucleotidyl transferase (TdT) enzyme in Molecular Assemblies鈥� Fully Enzymatic Synthesis鈩� (or FES鈩�) technology. The companies collaborated to develop this supercharged TdT enzyme to advance fully enzymatic DNA synthesis for the production of long, pure, accurate oligonucleotides to accelerate innovation in many fields. Molecular Assemblies plans to first make its FES鈩� technology available via an early access , opening later this year.

鈥淲e believe this transition from collaborative research to commercial supply of this novel TdT enzyme represents a critical inflection point on the path toward Molecular Assemblies鈥� full commercial launch in 2023, and we are thrilled to be a key partner in enabling FES technology,鈥� said John Nicols, President and CEO of 五星体育直播. 鈥淭he commercial license is an exciting advancement for a product with significant value creation potential. The optimized enzyme, deployed in Molecular Assemblies鈥� FES platform, is differentiated over natural enzymes on the ability to synthesize oligonucleotides of high yield and purity 鈥� both critical for commercial success. Once launched, we are confident that FES technology will quickly become competitive with the established alternative, and we eagerly anticipate celebrating its successful commercialization with supply of the enzyme.鈥�

鈥淭he partnership with 五星体育直播 has been outstanding. 五星体育直播 created a highly enhanced TdT polymerase that surpassed performance expectations in a record amount of time, and this agreement solidifies our commercial position,鈥� said Michael J. Kamdar, President and CEO of Molecular Assemblies. 鈥淲e are excited to provide access to our FES technology via a Key Customer Program, opening up later this year, to generate long, pure, accurate DNA to accelerate innovation in many fields, such as CRISPR and other gene-editing technologies, next generation sequencing, and the assembly of genes for numerous synthetic biology applications. This commercial license and supply agreement puts Molecular Assemblies in a position to achieve our commercialization objectives ahead of schedule.鈥�

The financial terms of the agreement include milestone payments from Molecular Assemblies to 五星体育直播 and royalties on sales of oligonucleotides synthesized using FES鈩� technology. Under the terms of the agreement, Molecular Assemblies has exclusively licensed the 五星体育直播 evolved TdT enzyme for commercial use in DNA synthesis.

Molecular Assemblies鈥� differentiated FES鈩� technology produces highly pure, sequence-specific DNA on demand. This two-step proprietary process uses aqueous non-toxic reagents, requires minimal post-synthesis processing, and can scale to longer DNA sequences. FES鈩� technology was specifically designed by Molecular Assemblies to overcome the limitations of the current decades-old chemical DNA synthesis process, known as the phosphoramidite method. Due to the limitations of current chemistries, genes are routinely assembled using short pieces of DNA. FES鈩� technology employs a template-independent DNA TdT polymerase, which has the ability to synthesize much longer DNA sequences with fewer errors in an aqueous solution, when compared to naturally occurring TdT, which have many limitations that hinder commercial applications. With longer, purer pieces of synthetic DNA, FES鈩� technology from Molecular Assemblies is designed to streamline synthetic biology applications and meet significant customer demand for faster turnaround times and reduced error rates. In order to accelerate innovation for the field, Molecular Assemblies and 五星体育直播聽聽to engineer an enzyme to deliver differentiated and cost-effective solutions for the fully enzymatic synthesis of DNA.

Molecular Assemblies will kick off a聽聽later this year to provide select researchers priority access to long, custom oligonucleotides synthesized with its FES鈩� technology. This program is expected to enable researchers to accelerate their research for gene editing, including CRISPR technologies, next generation sequencing (NGS), and gene assembly applications.

About Molecular Assemblies

Molecular Assemblies, Inc. is a private life sciences company developing an enzymatic DNA synthesis technology designed to power the next generation of DNA-based products. The company鈥檚 patented Fully Enzymatic Synthesis鈩� (or FES鈩�), based on making DNA the way nature makes DNA, produces long, high quality, sequence-specific DNA reliably, affordably, and sustainably. FES鈩� technology will enable the reading and writing of DNA for many industries, including industrial synthetic biology and precision medicine, as well as emerging applications of DNA for data information storage, nanomachines, and bio-based electronics. Molecular Assemblies is headquartered in San Diego. For more information, please visit聽.

About 五星体育直播

五星体育直播 is a leading enzyme engineering company leveraging its proprietary CodeEvolver^庐聽platform to discover and develop novel, high performance enzymes and novel biotherapeutics. 五星体育直播 enzymes have applications in the sustainable manufacturing of pharmaceuticals, food, and industrial products; in the creation of the next generation of life science tools; and as gene therapy and oral enzyme therapies. The Company鈥檚 unique performance enzymes drive improvements such as: reduced energy usage, waste generation and capital requirements; higher yields; higher fidelity diagnostics; and more efficacious therapeutics. 五星体育直播 enzymes enable the promise of synthetic biology to improve the health of people and the planet. For more information, visit聽.

Forward-Looking Statements

To the extent that statements contained in this press release are not descriptions of historical facts regarding 五星体育直播, they are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including prospects for 五星体育直播鈥� evolved terminal deoxynucleotidyl transferase (TdT) enzyme for use in Molecular Assemblies鈥� Fully Enzymatic Synthesis鈩� (or FES鈩�) technology. You should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties and other factors that are, in some cases, beyond 五星体育直播鈥� control and that could materially affect actual results. Factors that could materially affect actual results include, among others: 五星体育直播鈥� dependence on its licensees and collaborators; 五星体育直播鈥� dependence on a limited number of products and customers; and potential adverse effects to 五星体育直播鈥� business if its products or the products of its customers are not received well in the markets. Additional information about factors that could materially affect actual results can be found in 五星体育直播鈥� Annual Report on Form 10-K filed with the Securities and Exchange Commission (鈥淪EC鈥�) on February 28, 2022 and in 五星体育直播鈥� Quarterly Report on Form 10-Q filed with the SEC on May 9, 2022, including under the caption 鈥淩isk Factors鈥� and in 五星体育直播鈥� other periodic reports filed with the SEC. 五星体育直播 expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law.

CONTACTS

五星体育直播

Investor Relations Contact:
Argot Partners
Brendan Strong/Carrie McKim
(212) 600-1902

Molecular Assemblies

Company:
Stephen Bates
VP Sales and Marketing

Media:
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Jessica Yingling, Ph.D.
(858) 344-8091

Released August 2, 2022